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Each MR image was normalized to Montreal Neurological Institute (MNI) space using an affine linear plus non-linear registration (Bioimage Suite 2.5), to extract the ROIs (Zakiniaeiz et al., BP ND (the ratio at equilibrium of specifically bound radioligand to that of the concentration of nondisplaceable radioligand in tissue) for pre- and post-amphetamine scans, as previously validated and described (Zakiniaeiz et al., BP ND is an index of D 2 R availability that is proportional to the number of available binding sites